HCID 20497520、化合物 → Ethyl 4-(4-aminobutyl)piperazine-1-carboxylate

HRID 2166923ノート

反応式

HRID 2166923 の反応式
[C:1]([CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:8][CH2:7]1)#[N:2]>N.C(O)C.[Rh]>[NH2:2][CH2:1][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][N:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:10][CH2:11]1

参加物

5

反応物 1

HCID 20497520HCID 20497520、化合物

生成物 1

HCID 20497516Ethyl 4-(4-aminobutyl)piperazine-1-carboxylate収率 32.7%

試薬・触媒・溶媒 3

HCID 23948Rhodium触媒HCID 222Ammonia溶媒HCID 702Ethanol溶媒

実験手順

60 g of ethyl 4-(3-cyanopropyl)-piperazine-1-carboxylate were dissolved in a 10% w/w solution of ammonia in ethanol and 6 g of 5% rhodium on alumina were added thereto. The mixture was cooled to room temperature and filtered. The filtrate was evaporated to dryness under vacuum and the residual oil was distilled under reduced pressure to obtain 20 g of ethyl 4-(4-aminobutyl)-piperazine-1-carboxylate with a boiling point of 126°-130° C. at 0.15 to 0.2 mm Hg.

後処理

  1. additionwere added
  2. filtrationfiltered
  3. customThe filtrate was evaporated to dryness under vacuum
  4. distillationthe residual oil was distilled under reduced pressure

出典と根拠

ORDレコード
ord-febb1e1e9fd94a0aae15d11aa63c7d03
出典データセット
uspto-grants-1983_06
特許番号
US04390697

反応ノート

読み込み中…