化工社化工社 化学情報印刷レポート · 研究参考用
Citric Acid → Apomorphine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Citric Acid | HCID 311 | — |
| 反応物 | Mannitol | HCID 6251 | — |
| 反応物 | 4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride (1:1), (6aR)- | HCID 9410 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Apomorphine | HCID 6005 | — |
反応手順
Gelatin and mannitol are dispersed in purified water and mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Apomorphine hydrochloride is added and the mixture was again homogenized to ensure complete dissolution of the apomorphine hydrochloride. The pH of the solution is adjusted to about 3.0 (i.e., by addition of a suitable acid, such as citric acid). The solution is then poured onto a sheet and dried in a heated oven.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09044475B2 |
| 出典データセット | uspto-grants-2015_06 |
| ORD ID | ord-209d9e9339364d4db7de1f3c96ee0a96 |
| 出典メモ | uspto-grants-2015_06 |