HCID 86627645、化合物 → HCID 86627646、化合物
反応式
[Cl:1]C(OC([N:7]1[CH2:12][CH:11]=[C:10]([C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[NH:20][C:21]([C:23]2[CH:28]=[CH:27][N:26]=[C:25]([Cl:29])[CH:24]=2)=[O:22])[CH2:9][CH2:8]1)=O)C>CO>[ClH:1].[Cl:29][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][N:26]=1)[C:21]([NH:20][C:14]1[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:13]=1[C:10]1[CH2:11][CH2:12][NH:7][CH2:8][CH:9]=1)=[O:22]参加物
3
実験手順
Crude 4-{5-chloro-2-[(2-chloro-pyridine-4-carbonyl)-amino]phenyl}-3,6-dihydro-2H-pyridine-1-carboxylic acid 1-chloro-ethyl ester (550 mg) was dissolved in methanol (25 ml) in and heated to reflux for 16 hours. Evaporation afforded the crude title product (465 mg). Retention Time HPLC 1.48 min; MS (ES+) 350, 348 (M+H+).
後処理
- temperatureheated
- temperatureto reflux for 16 hours
- customEvaporation