Sodium Bicarbonate → 3-Phenyl-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)propanenitrile

HRID 2167442ノート

反応式

HRID 2167442 の反応式
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH:18]([C:26]#[N:27])[CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:13][CH:14]=2)[CH2:9]1)=O)(C)(C)C.C([O-])(O)=O.[Na+]>C(O)=O>[C:20]1([CH2:19][CH:18]([C:12]2[CH:11]=[C:10]3[C:15]([CH2:16][CH2:17][NH:8][CH2:9]3)=[CH:14][CH:13]=2)[C:26]#[N:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 66978151tert-Butyl-7-(1-cyano-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

生成物 1

HCID 667475123-Phenyl-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)propanenitrile収率 85.8%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

0.171 mmol tert-butyl-7-(1-cyano-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate were dissolved in 1.3 ml formic acid and stirred at room temperature for 1 h. After addition of saturated NaHCO3 solution the mixture was extracted with EtOAc. The combined organic layers were dried over MgSO4 and filtered. Evaporation of the solvent gave 38.5 mg of solid material (86%).

後処理

  1. extractionwas extracted with EtOAc
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. filtrationfiltered
  4. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-182c55481b8640a6a295e1b419dd7cf6
出典データセット
uspto-grants-2015_06
特許番号
US09045459B2

反応ノート

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