Chloroacetaldehyde → HCID 90427811、化合物
反応式
[NH2:1][C:2]1[N:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[C:3]=1[C:4]#[N:5].Cl[CH2:13][CH:14]=O>O>[CH3:10][C:8]1[N:9]2[CH:13]=[CH:14][N:1]=[C:2]2[C:3]([C:4]#[N:5])=[C:6]([CH3:11])[CH:7]=1参加物
4
実験手順
To a stirred solution of compound 2-amino-4,6-dimethylnicotinonitrile (1 equiv.) in water was added chloroacetaldehyde (55% aq. solution) (1.2 equiv.) and reaction was heated at 80 oC for 16 h. On completion, it was quenched by 1N NaOH till pH 8. Solid precipitated was filtered and vacuum dried to afford the title compound (75% yield).
後処理
- temperaturewas heated at 80 oC for 16 h
- customOn completion, it was quenched by 1N NaOH till pH 8
- customSolid precipitated
- filtrationwas filtered
- customvacuum dried
出典と根拠
- ORDレコード
- ord-44a3673fc57c4ef3b2740055c7d326b1
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09045477B2
反応ノート
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