2-Methyl-2H-indazole-7-carbonitrile → HCID 44119221、化合物

HRID 2167684ノート

反応式

HRID 2167684 の反応式
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([C:11]#[N:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1>CO.N.[Ni]>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([CH2:11][NH2:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1

参加物

5

反応物 1

HCID 441192602-Methyl-2H-indazole-7-carbonitrile

生成物 1

HCID 44119221HCID 44119221、化合物

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 222Ammonia溶媒HCID 887Methanol溶媒

実験手順

To a solution of 2-methyl-2H-indazole-7-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (quant. yield).

後処理

  1. customReaction mass
  2. customOn completion of reaction, it
  3. filtrationwas filtered through celite bed and filtrate
  4. concentrationwas concentrated

出典と根拠

ORDレコード
ord-08b61626b11249f295c4aeb7010332f1
出典データセット
uspto-grants-2015_06
特許番号
US09045477B2

反応ノート

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