Ethanol → 2-bromo-1-(5-fluoropyridin-3-yl)ethan-1-one hydrobromide

HRID 2167694ノート

反応式

HRID 2167694 の反応式
C(O)C.[F:4][C:5]1[CH:6]=[C:7]([C:11](=[O:13])[CH3:12])[CH:8]=[N:9][CH:10]=1.[BrH:14].C(O)C.BrBr>C(O)(=O)C>[BrH:14].[Br:14][CH2:12][C:11]([C:7]1[CH:8]=[N:9][CH:10]=[C:5]([F:4])[CH:6]=1)=[O:13]

参加物

6

反応物 4

HCID 702EthanolHCID 24408BromineHCID 23002992HCID 23002992、化合物HCID 450796401-(5-Fluoropyridin-3-yl)ethan-1-one

生成物 1

HCID 867207462-bromo-1-(5-fluoropyridin-3-yl)ethan-1-one hydrobromide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
70 °C

実験手順

To an ethanol (5.0 mL) solution of 1-(5-fluoropyridin-3-yl)ethanone (0.50 g), acetic acid (6.0 mL) was added, then a 20 to 30% hydrobromic acid/ethanol solution (1.0 mL) and bromine (0.30 mL) were added under ice cooling, and the resultant was stirred at 70° C. for 45 minutes. The reaction solution was concentrated under reduced pressure to obtain the title compound (1.30 g) as a faint orange solid.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-9af023fb518c472c81efb75a6807aec1
出典データセット
uspto-grants-2015_06
特許番号
US09045466B2

反応ノート

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