Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate → (R)-5-(2-(3,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid

HRID 2167810

反応式

HRID 2167810 の反応式
Cl.[F:2][C:3]1[CH:4]=[C:5]([C@H:10]2[CH2:14][CH2:13][CH2:12][NH:11]2)[CH:6]=[C:7]([F:9])[CH:8]=1.Br[C:16]1[CH:21]=[CH:20][N:19]2[N:22]=[CH:23][C:24]([C:25]([O:27]CC)=[O:26])=[C:18]2[CH:17]=1>>[F:9][C:7]1[CH:6]=[C:5]([C@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[C:16]2[CH:21]=[CH:20][N:19]3[N:22]=[CH:23][C:24]([C:25]([OH:27])=[O:26])=[C:18]3[CH:17]=2)[CH:4]=[C:3]([F:2])[CH:8]=1

参加物

3

反応物 2

HCID 53249841Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylateHCID 89618463(r)-2-(3,5-Difluorophenyl)pyrrolidine hydrochloride

生成物 1

HCID 89618792(R)-5-(2-(3,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid

実験手順

The title compound was prepared by a method substantially similar to that mentioned in step-5 and step-6 of example-3 using (R)-2-(3,5-Difluorophenyl)pyrrolidine hydrochloride (step-1) and Ethyl 5-bromo-pyrazolo[1,5-a]pyridine-3-carboxylate to afford the product as white solid. MS (ESI): m/z 344.1 (M+H).

出典と根拠

ORDレコード
ord-4a066e0542bd4a43b259a669fb1a787f
出典データセット
uspto-grants-2015_06
特許番号
US09045479B2

関連ノート

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