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Dimethylformamide diethylacetal → 7-benzyl-octahydro-5H,9bH-2a,4a,7,9a-tetraazacycloocta[cd]pentalene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide diethylacetal | HCID 70913 | — |
| 反応物 | 1-Benzyl-1,4,7,10-tetraazacyclododecane | HCID 10084082 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 7-benzyl-octahydro-5H,9bH-2a,4a,7,9a-tetraazacycloocta[cd]pentalene | HCID 10967659 | 96% |
反応手順
A solution of 1-benzyl-1,4,7,10-tetraazacyclododecane (4 g; 0.015 mol) and dimethylformamide diethylacetal (6.88 g; 0.0467 mol) in benzene (40 ml) is heated at 80 C. and the azeotropic mixture ethanol-benzene is distilled away. When the conversion is ended, the solvent is evaporated under reduced pressure and the final product is obtained as a yellow oil (4.0 g). Yield 96%
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05424423 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-45ff071bbebe4e44a0b56ce40e0262de |
| 出典メモ | uspto-grants-1995_06 |