4-[3-(Dimethylamino)propoxy]benzonitrile → 4-[3-(Dimethylamino)propoxy]benzylamine

HRID 2168035ノート

反応式

HRID 2168035 の反応式
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1>CO.[Ni]>[NH2:12][CH2:11][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:1])[CH3:15])=[CH:14][CH:13]=1

参加物

4

反応物 1

HCID 118583624-[3-(Dimethylamino)propoxy]benzonitrile

生成物 1

HCID 214653844-[3-(Dimethylamino)propoxy]benzylamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

4-(3-(Dimethylamino)propoxy)benzonitrile (300 mg) in methanol (20 mL) was treated with Raney nickel (wet, 1.5 g) under H2 (30 psi) for 4 hour. The insoluble material was filtered off and the filtrate was concentrated to provide the title compound.

後処理

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-0d3d4d386feb4faabda01e1db0770d9c
出典データセット
uspto-grants-2015_06
特許番号
US09045475B2

反応ノート

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