Hydrochloric Acid → 3-(2-Morpholin-4-YL-ethoxy)-benzoic acid

HRID 2168224ノート

反応式

HRID 2168224 の反応式
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([CH:18]=[CH:19][CH:20]=2)[C:13]([O:15]CC)=[O:14])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl>>[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([CH:18]=[CH:19][CH:20]=2)[C:13]([OH:15])=[O:14])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 58089039Ethyl 3-{[2-(4-morpholinyl)ethyl]oxy}benzoate

生成物 1

HCID 230099053-(2-Morpholin-4-YL-ethoxy)-benzoic acid

実験手順

To the material of ethyl 3-{[2-(4-morpholinyl)ethyl]oxy}benzoate D47 (98 mg) was added HCl (0.5 mL, 16.46 mmol) at room temperature. The reaction was stirred at 100° for 2.5 hours. The mixture was concentrated in vacuo. To the residue was added 2 ml of ether and stirred for 0.5 hours, filtered. The filtrate was evaporated in vacuo to give the expected product D51 in 90 mg, as a white solid. LCMS Retention time=0.84 mins, [M+H]+ 252 (5 min run)

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. additionTo the residue was added 2 ml of ether
  3. stirringstirred for 0.5 hours
  4. filtrationfiltered
  5. customThe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-7c03c471a6314b659d13ef3203e41f47
出典データセット
uspto-grants-2015_06
特許番号
US09045485B2

反応ノート

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