(4aR,6R,8aS)-8a-(2,4-difluoro-5-{[(2,2,2-trifluoroethyl)amino]methyl}phenyl)-6-(fluoromethyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine → (4aR,6S,8aS)-8a-(2,4-difluoro-5-{[(2,2,2-trifluoroethyl)amino]methyl}phenyl)-6-methyl-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine

反応式

[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([CH2:9][NH:10][CH2:11][C:12]([F:15])([F:14])[F:13])=[CH:4][C:3]=1[C@:16]12[CH2:25][O:24][C@@H:23]([CH3:26])[CH2:22][C@H:21]1[CH2:20][S:19][C:18]([NH:27]C(=O)C1C=CC=CC=1)=[N:17]2.FC1C=C(F)C(CNCC(F)(F)F)=CC=1[C@]12CO[C@@H](CF)C[C@H]1CSC(N)=N2>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([CH2:9][NH:10][CH2:11][C:12]([F:14])([F:15])[F:13])=[CH:4][C:3]=1[C@:16]12[CH2:25][O:24][C@@H:23]([CH3:26])[CH2:22][C@H:21]1[CH2:20][S:19][C:18]([NH2:27])=[N:17]2