[5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid → HCID 67144762、化合物
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]([O:13][CH3:14])=[O:12])=[C:6](B(O)O)[CH:7]=1.[C:15]1([S:21]N2C(=O)C3C(=CC=CC=3)C2=O)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>O1CCOCC1.OC1C(C(C)C)=CC(C(C)C)=CC=1C(O[Cu])=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]([O:13][CH3:14])=[O:12])=[C:6]([S:21][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:7]=1参加物
5
実験手順
5-Fluoro-2-(methoxycarbonyl)phenylboronic acid (1.00 g), 2-(phenylthio)isoindoline-1,3-dione (0.86 g), and (2-hydroxy-3,5-diisopropylbenzoyloxy)copper (0.29 g) were stirred in dioxane (15 mL) at 50° C. for 24 hours. The reaction mixture was chromatographed on silica gel with 5% ethyl acetate/hexanes.
後処理
- customThe reaction mixture was chromatographed on silica gel with 5% ethyl acetate/hexanes
出典と根拠
- ORDレコード
- ord-c04dee848f264e7285f7b11a0c72cc52
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09045420B2
反応ノート
読み込み中…