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Hydrochloric Acid → 3-(4-Benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Cesium fluoride | HCID 25953 | — |
| 反応物 | (Trifluoromethyl)trimethylsilane | HCID 552549 | — |
| 反応物 | Methyl 2-(4-benzyloxyphenyl)acetate | HCID 2756645 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-(4-Benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one | HCID 67387207 | — |
反応手順
A mixture of (4-benzyloxy-phenyl)-acetic acid methyl ester (11.7 mmol, 3.0 g), trimethyl-trifluoromethyl-silane and cesium fluoride in THF may be stirred at room temperature for 2 h. Hydrochloride may be added upon consumption of ester as indicated by TLC. The mixture may be stirred further at room temperature until the intermediate disappears as indicated by TLC to provide 3-(4-benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09045461B2 |
| 出典データセット | uspto-grants-2015_06 |
| ORD ID | ord-635bf373a0984232bca548a6e1588bee |
| 出典メモ | uspto-grants-2015_06 |