(1-Phenylcyclopentyl)acetonitrile → 2-(1-Phenyl-cyclopentyl)-acetamidine HCl salt

HRID 2169157ノート

反応式

HRID 2169157 の反応式
[C:1]1([C:7]2([CH2:12][C:13]#[N:14])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[Cl:16]C1C=CC=CC=1C1C=CC=CC=1CC(N)=[NH:31]>>[ClH:16].[C:1]1([C:7]2([CH2:12][C:13]([NH2:31])=[NH:14])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

3

反応物 2

HCID 223258(1-Phenylcyclopentyl)acetonitrileHCID 867257832-(2'-Chloro-biphenyl-2-yl)-acetamidine hydrochloride salt

生成物 1

HCID 867258072-(1-Phenyl-cyclopentyl)-acetamidine HCl salt収率 77.7%

実験手順

2-(1-Phenyl-cyclopentyl)-acetamidine HCl salt (26-01) (4.2 g, 77.7%) was synthesized from (1-phenyl-cyclopentyl)-acetonitrile (25-01) (4.2 g, 22.703 mmol) as a white gummy solid as a crude product following the procedure as described for 2-(2′-chloro-biphenyl-2-yl)-acetamidine hydrochloride salt (5-02).

出典と根拠

ORDレコード
ord-571c0a5794a14e1cb8664a6638d6ff3c
出典データセット
uspto-grants-2015_06
特許番号
US09045486B2

反応ノート

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