2-(2'-Chloro-biphenyl-2-yl)-acetamidine hydrochloride salt → 2-[1-(4-chlorophenyl)-cyclopentyl]-acetamidine HCl salt
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:13][C:14]#[N:15])[CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl.ClC1C=CC=CC=1C1C=CC=CC=1CC(N)=[NH:32]>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([CH2:13][C:14]([NH2:32])=[NH:15])[CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:6][CH:7]=1参加物
3
実験手順
2-[1-(4-chlorophenyl)-cyclopentyl]-acetamidine HCl salt (26-02) (6 g, 80.21%) was synthesized from [1-(4-chlorophenyl)-cyclopentyl]-acetonitrile (25-02) (6 g, 27.39 mmol) as a white gummy solid as a crude product following the procedure as described for 2-(2′-chloro-biphenyl-2-yl)-acetamidine hydrochloride salt (5-02).
出典と根拠
- ORDレコード
- ord-a75133f08beb425bb7194f80599f2554
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09045486B2
反応ノート
読み込み中…