Cyclobutylamine → [2-(tert-Butyl-dimethylsilanyloxy)-ethyl]-cyclobutyl-amine

反応式

[Si:1]([O:8][CH2:9][CH2:10][NH:11][CH:12]1[CH2:16][CH2:15][CH2:14]C1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].C1(N)CCC1.[Si](OCC=O)(C(C)(C)C)(C)C>>[Si:1]([O:8][CH2:9][CH2:10][NH:11][CH:12]1[CH2:16][CH2:15][CH2:14]1)([C:4]([CH3:5])([CH3:6])[CH3:7])([CH3:2])[CH3:3]

参加物

反応物 3

HCID 75645Cyclobutylamine

HCID 41877882-((Tert-butyldimethylsilyl)oxy)acetaldehyde

HCID 86725959[2-(Tert-butyl-dimethylsilanyloxy)-ethyl]-cyclopentylamine

生成物 1

HCID 86725964[2-(tert-Butyl-dimethylsilanyloxy)-ethyl]-cyclobutyl-amine

実験手順

This compound was prepared following the same method as described for [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-cyclopentyl-amine (8e) from cyclobutylamine (1 g, 14.27 mmol) and 2-(tert-butyl-dimethylsilanyloxy)acetaldehyd (2.6 mg, 14.26 mmol). The product was obtained as a yellow gummy mass (400 mg, 12.22%).