HCID 178455251、化合物 → HCID 178519980、化合物

HRID 2169445ノート

反応式

HRID 2169445 の反応式
OCCN(C)C(C1C(OCC2C=CC=CC=2)=C(O)N=C(CC2(N3C4=NC=CC=C4C=C3)CCCC2)N=1)=O.[Si]([O:45][CH2:46][CH2:47][N:48]([CH2:81][CH:82]1[CH2:84][CH2:83]1)[C:49]([C:51]1[C:56]([O:57][CH2:58][C:59]2[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=2)=[C:55]([OH:65])[N:54]=[C:53]([CH2:66][C:67]2([N:72]3[C:76]4=[N:77][CH:78]=[CH:79][CH:80]=[C:75]4[CH:74]=[CH:73]3)[CH2:71][CH2:70][CH2:69][CH2:68]2)[N:52]=1)=[O:50])(C(C)(C)C)(C)C>>[CH:82]1([CH2:81][N:48]([CH2:47][CH2:46][OH:45])[C:49]([C:51]2[C:56]([O:57][CH2:58][C:59]3[CH:60]=[CH:61][CH:62]=[CH:63][CH:64]=3)=[C:55]([OH:65])[N:54]=[C:53]([CH2:66][C:67]3([N:72]4[C:76]5=[N:77][CH:78]=[CH:79][CH:80]=[C:75]5[CH:74]=[CH:73]4)[CH2:68][CH2:69][CH2:70][CH2:71]3)[N:52]=2)=[O:50])[CH2:84][CH2:83]1

参加物

3

反応物 2

HCID 178455251HCID 178455251、化合物HCID 178484643HCID 178484643、化合物

生成物 1

HCID 178519980HCID 178519980、化合物

実験手順

5-Benzyloxy-6-hydroxy-2-(1-pyrrolo[2,3-b]pyridin-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid cyclopropylmethyl-(2-hydroxyethyl)-amide (414) was prepared following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-pyrrolo[2,3-b]pyridin-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid (2-hydroxyethyl)-methyl-amide (406) from 5-benzyloxy-6-hydroxy-2-(1-pyrrolo[2,3-b]pyridin-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-cyclopropylmethyl-amide (413) (170 mg, 0.26 mmol) and the product was obtained as white sticky solid (140 mg, crude).

後処理

  1. customthe product was obtained as white sticky solid (140 mg, crude)

出典と根拠

ORDレコード
ord-0fa7ca02f4164890b79aaa1d16089e0a
出典データセット
uspto-grants-2015_06
特許番号
US09045486B2

反応ノート

読み込み中…