HCID 178455284、化合物 → HCID 178519979、化合物

HRID 2169453ノート

反応式

HRID 2169453 の反応式
C1(N(CCO)C(C2C(OCC3C=CC=CC=3)=C(O)N=C(CC3(N4C5=NC=CC=C5C=C4)CCCC3)N=2)=O)CC1.[Si]([O:47][CH2:48][CH2:49][N:50]([CH:83]1[CH2:86][O:85][CH2:84]1)[C:51]([C:53]1[C:58]([O:59][CH2:60][C:61]2[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=2)=[C:57]([OH:67])[N:56]=[C:55]([CH2:68][C:69]2([N:74]3[C:78]4=[N:79][CH:80]=[CH:81][CH:82]=[C:77]4[CH:76]=[CH:75]3)[CH2:73][CH2:72][CH2:71][CH2:70]2)[N:54]=1)=[O:52])(C(C)(C)C)(C)C>>[OH:47][CH2:48][CH2:49][N:50]([CH:83]1[CH2:86][O:85][CH2:84]1)[C:51]([C:53]1[C:58]([O:59][CH2:60][C:61]2[CH:62]=[CH:63][CH:64]=[CH:65][CH:66]=2)=[C:57]([OH:67])[N:56]=[C:55]([CH2:68][C:69]2([N:74]3[C:78]4=[N:79][CH:80]=[CH:81][CH:82]=[C:77]4[CH:76]=[CH:75]3)[CH2:73][CH2:72][CH2:71][CH2:70]2)[N:54]=1)=[O:52]

参加物

3

反応物 2

HCID 178455284HCID 178455284、化合物HCID 178519977HCID 178519977、化合物

生成物 1

HCID 178519979HCID 178519979、化合物

実験手順

5-Benzyloxy-6-hydroxy-2-(1-pyrrolo[2,3-b]pyridin-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid (2-hydroxyethyl)-oxetan-3-yl-amide (422) was prepared following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-pyrrolo[2,3-b]pyridin-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid cyclopropyl-(2-hydroxyethyl)-amide (418) from 5-benzyloxy-6-hydroxy-2-(1-pyrrolo[2,3-b]pyridin-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-oxetan-3-yl-amide (421) (180 mg, 0.27 mmol) and was obtained as light brown sticky solid (220 mg, crude).

後処理

  1. customwas obtained as light brown sticky solid (220 mg, crude)

出典と根拠

ORDレコード
ord-dc7dc6cd128d4511a1ba172d75eb23b5
出典データセット
uspto-grants-2015_06
特許番号
US09045486B2

反応ノート

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