Methyl N-(triethylammoniosulfonyl)carbamate → (S)-4-Amino-N-(1-cyano-2-(4-(2-methoxypyridin-4-yl)phenyl)ethyl)tetrahydro-2H-pyran-4-carboxamide

HRID 216964ノート

反応式

HRID 216964 の反応式
[NH2:1][C:2](=O)[C@@H:3]([NH:19][C:20]([C:22]1([NH:28]C(=O)OC(C)(C)C)[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1)=[O:21])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([O:17][CH3:18])[CH:12]=2)=[CH:7][CH:6]=1.CC[N+](S(N=C(OC)[O-])(=O)=O)(CC)CC>ClCCl.C(O)=O>[NH2:28][C:22]1([C:20]([NH:19][C@H:3]([C:2]#[N:1])[CH2:4][C:5]2[CH:6]=[CH:7][C:8]([C:11]3[CH:16]=[CH:15][N:14]=[C:13]([O:17][CH3:18])[CH:12]=3)=[CH:9][CH:10]=2)=[O:21])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1

参加物

5

反応物 2

HCID 2724994Methyl N-(triethylammoniosulfonyl)carbamateHCID 59568572(S)-tert-Butyl 4-(1-amino-3-(4-(2-methoxypyridin-4-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

生成物 1

HCID 49783906(S)-4-Amino-N-(1-cyano-2-(4-(2-methoxypyridin-4-yl)phenyl)ethyl)tetrahydro-2H-pyran-4-carboxamide収率 58.2%

試薬・触媒・溶媒 2

HCID 284Formic Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

(S)-tert-Butyl 4-(1-amino-3-(4-(2-methoxypyridin-4-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 26, step (i), 214 mg) in dichloromethane (10 mL) was treated with Burgess' reagent (205 mg) and the mixture was stirred at room temperature for 18 h. The solvent was evaporated to give a residue that was dissolved in formic acid (2 mL) which was heated at 50° C. for 15 min. The mixture was evaporated and then methanol was added and the solvent was evaporated. The product was purified by reversed phase HPLC using methanol in 0.1% aqueous TFA as eluent. The residue was converted to the free base by elution through a PL-HCO3 MP cartridge in dichloromethane/methanol to afford the titled compound (95 mg).

後処理

  1. customThe solvent was evaporated
  2. customto give a residue that
  3. temperaturewas heated at 50° C. for 15 min
  4. customThe mixture was evaporated
  5. additionmethanol was added
  6. customthe solvent was evaporated
  7. customThe product was purified by reversed phase
  8. washThe residue was converted to the free base by elution through a PL-HCO3 MP cartridge in dichloromethane/methanol

出典と根拠

ORDレコード
ord-4d0b585ba0e146bb8f93bb28d35fe8f0
出典データセット
uspto-grants-2012_06
特許番号
US08193239B2

反応ノート

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