Methyl N-(triethylammoniosulfonyl)carbamate → HCID 59568591、化合物

HRID 216966

反応式

HRID 216966 の反応式
[NH2:1][C:2](=O)[C@@H:3]([NH:26][C:27]([C:29]1([NH:35][C:36](=[O:42])[O:37][C:38]([CH3:41])([CH3:40])[CH3:39])[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1)=[O:28])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)(=[O:19])=[O:18])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1.CC[N+](S(N=C(OC)[O-])(=O)=O)(CC)CC>ClCCl>[C:2]([C@@H:3]([NH:26][C:27]([C:29]1([NH:35][C:36](=[O:42])[O:37][C:38]([CH3:40])([CH3:39])[CH3:41])[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1)=[O:28])[CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:12]=[CH:13][C:14]([S:17]([N:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)(=[O:19])=[O:18])=[CH:15][CH:16]=2)=[CH:9][CH:10]=1)#[N:1]

参加物

4

反応物 2

HCID 2724994Methyl N-(triethylammoniosulfonyl)carbamateHCID 59568573(S)-tert-Butyl 4-(1-amino-3-(4'-(morpholinosulfonyl)biphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

生成物 1

HCID 59568591HCID 59568591、化合物収率 90.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(S)-tert-Butyl 4-(1-amino-3-(4′-(morpholinosulfonyl)biphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 27, step (i), 0.24 g) in dichloromethane (10 mL) was treated with Burgess' reagent (0.185 g) and the mixture was stirred at room temperature for 18 h. The solvent was removed under reduced pressure and the residue was purified by chromatography on silica eluting with ethyl acetate/isohexane (1:1) to afford the sub-titled compound (210 mg).

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was purified by chromatography on silica eluting with ethyl acetate/isohexane (1:1)

出典と根拠

ORDレコード
ord-8d3edc69837b43fe88bcc137aefb2f1a
出典データセット
uspto-grants-2012_06
特許番号
US08193239B2

関連ノート

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