Bromine → 6-Bromo-4,5-dichloro-2,3-dihydropyridazin-3-one
反応式
[Cl:1][C:2]1[CH:3]=[N:4][NH:5][C:6](=[O:9])[C:7]=1[Cl:8].[Br:10]Br>O>[Br:10][C:3]1[C:2]([Cl:1])=[C:7]([Cl:8])[C:6](=[O:9])[NH:5][N:4]=1参加物
4
反応条件
- 温度
- 180 °C
実験手順
4,5-dichloro-1H-pyridazin-6-one (1.95 g, 11.8 mmol) and bromine (0.73 ml, 14.2 mmol) are suspended in water (10 ml) and the mixture heated under microwave irradiation to 180° C. for 30 min. The resulting reaction mixture is filtered and the crude solid obtained washed thoroughly with water, then DCM, to yield 3-bromo-4,5-dichloro-1H-pyridazin-6-one, 2.06 g, as a white solid (71.5% yield).
後処理
- customThe resulting reaction mixture
- filtrationis filtered
- customthe crude solid obtained
- washwashed thoroughly with water
出典と根拠
- ORDレコード
- ord-d4d69e86fc9d4d6885b4257c87c2b43f
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09049864B2
反応ノート
読み込み中…