Ether hydrochloride → Evenamide
反応式
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH:12](C(OC(C)(C)C)=O)[CH2:13][NH:14][CH2:15][C:16]([N:18]([CH3:20])[CH3:19])=[O:17])[CH:9]=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH3:4].[ClH:28].CCOCC>>[ClH:28].[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH2:12][CH2:13][NH:14][CH2:15][C:16]([N:18]([CH3:20])[CH3:19])=[O:17])[CH:9]=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH3:4]参加物
3
実験手順
A solution of 2-[2-(3-butoxyphenyl)-(tert-butoxycarbonyl)ethylamino]-N,N-dimethylacetamide (9.6 g, 25.3 mmol) in HCl/Et2O (127 ml) was stirred at room temperature for 16 h. The solvent was evaporated under reduced pressure, the residue was ground with a mixture of Et2O/iPr2O 50/50, filtered and washed with Et2O/iPr2O to obtain the title compound as white solid (1.71 g, yield 95%).
後処理
- customThe solvent was evaporated under reduced pressure
- additionthe residue was ground with a mixture of Et2O/iPr2O 50/50
- filtrationfiltered
- washwashed with Et2O/iPr2O