tert-Butylsulfinamide, (S)-(-)- → (S)-N-(5-bromo-6-(((tert-butylsulfinyl)imino)methyl)pyridin-2-yl)acetamide

関与物質

役割	名称	HCID	仕込み量
反応物	tert-Butylsulfinamide, (S)-(-)-	HCID 11355477	—
反応物	N-(5-Bromo-6-formyl-2-pyridinyl)acetamide	HCID 90280237	—
触媒	Copper Sulfate	HCID 24462	—
溶媒	Dichloromethane	HCID 6344	—
生成物	(S)-N-(5-bromo-6-(((tert-butylsulfinyl)imino)methyl)pyridin-2-yl)acetamide	HCID 90280385	—

反応手順

Copper(II) sulfate (anhydrous 2.8 g, 17.2 mmol) was added to a solution of N-(5-bromo-6-formylpyridin-2-yl)acetamide (crude material, assume 8.6 mmol) and (S)-2-methylpropane-2-sulfinamide (1.2 g, 9.4 mmol) in DCM (30 ml). The suspension was stirred overnight at room temperature. The reaction was filtered and washed with DCM (3×20 ml). The filtrate was concentrated. The crude product was purified by flash column (30% EtOAc/Hexanes). MS (m/z) 346.1 [M+H]+.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09050344B2
出典データセット	uspto-grants-2015_06
ORD ID	ord-32e67f315d79418688dd525d9f8d0186
出典メモ	uspto-grants-2015_06