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(3-(2,2,2-Trifluoroethyl)phenyl)boronic acid → N-(1-(6-amino-3-(3-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(5-fluoro-1H-indol-3-yl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (3-(2,2,2-Trifluoroethyl)phenyl)boronic acid | HCID 68852112 | — |
| 反応物 | N-(1-(6-amino-3-bromopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(5-fluoro-1H-indol-3-yl)acetamide | HCID 90281232 | — |
| 反応物 | (S)-5-(6-amino-2-(2-(3,5-difluorophenyl)-1-(2-(5-fluoro-1H-indol-3-yl)acetamido)ethyl)pyridin-3-yl)-2-fluorobenzamide | HCID 90281459 | — |
| 生成物 | N-(1-(6-amino-3-(3-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(5-fluoro-1H-indol-3-yl)acetamide | HCID 90281244 | — |
反応手順
The title compound was prepared according to the method presented for the synthesis of compound 1H of Example 1 utilizing 1G and (3-(2,2,2-trifluoroethyl)phenyl)boronic acid. 1H NMR (400 MHz, DMSO) δ 10.96 (s, 1H), 7.61-7.55 (m, 3H), 7.30 (dd, J=8.7, 4.6 Hz, 2H), 7.26-7.11 (m, 2H), 7.11-6.95 (m, 4H), 6.87 (t, J=9.4 Hz, 1H), 6.47 (m, 2H), 5.02 (d, J=6.6 Hz, 1H), 4.79-4.61 (m, 2H), 2.91 (m, 2H). MS (m/z) 599.2 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09050344B2 |
| 出典データセット | uspto-grants-2015_06 |
| ORD ID | ord-10677ce5ab6d4d0fb7fc79f326eb707e |
| 出典メモ | uspto-grants-2015_06 |