(2-Methoxypyridin-4-yl)boronic acid → N-(1-(6-amino-2'-methoxy-[3,4'-bipyridin]-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(5-fluoro-1H-indol-3-yl)acetamide

関与物質

役割	名称	HCID	仕込み量
反応物	(2-Methoxypyridin-4-yl)boronic acid	HCID 23546919	—
反応物	N-(1-(6-amino-3-bromopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(5-fluoro-1H-indol-3-yl)acetamide	HCID 90281232	—
反応物	(S)-5-(6-amino-2-(2-(3,5-difluorophenyl)-1-(2-(5-fluoro-1H-indol-3-yl)acetamido)ethyl)pyridin-3-yl)-2-fluorobenzamide	HCID 90281459	—
生成物	N-(1-(6-amino-2'-methoxy-[3,4'-bipyridin]-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(5-fluoro-1H-indol-3-yl)acetamide	HCID 90281345	—

反応手順

The title compound was prepared according to the method presented for the synthesis of compound 1H of Example 1 utilizing 1G and (2-methoxypyridin-4-yl)boronic acid. 1H NMR (400 MHz, DMSO) δ 10.89 (s, 1H), 7.96 (d, J=5.2 Hz, 1H), 7.25 (dd, J=8.9, 4.3 Hz, 2H), 7.14-7.10 (m, 3H), 6.88-6.80 (m, 3H), 6.67 (d, J=5.2 Hz, 1H), 6.45-6.38 (m, 5H), 5.00 (d, J=7.3 Hz, 1H), 3.75 (s, 2H), 2.89 (m, 2H). MS (m/z) 532.4 [M+H]+.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09050344B2
出典データセット	uspto-grants-2015_06
ORD ID	ord-54c318af6c014eb182b91e034d4a8141
出典メモ	uspto-grants-2015_06