N-(6-(1-amino-2-(3,5-difluorophenyl)ethyl)-5-bromopyridin-2-yl)acetamide hydrochloride → (R)-1-(5-bromo-2-(methylthio)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethanamine hydrochloride
反応式
[ClH:1].NC(C1N=C(NC(=O)C)C=CC=1Br)CC1C=C(F)C=C(F)C=1.[Br:24][C:25]1[C:26]([C@H:33]([NH:43][S@](C(C)(C)C)=O)[CH2:34][C:35]2[CH:40]=[C:39]([F:41])[CH:38]=[C:37]([F:42])[CH:36]=2)=[N:27][C:28]([S:31][CH3:32])=[N:29][CH:30]=1>>[ClH:1].[Br:24][C:25]1[C:26]([C@H:33]([NH2:43])[CH2:34][C:35]2[CH:40]=[C:39]([F:41])[CH:38]=[C:37]([F:42])[CH:36]=2)=[N:27][C:28]([S:31][CH3:32])=[N:29][CH:30]=1参加物
3
反応物 2
生成物 1
実験手順
The title compound (11F) was prepared according to the method presented for the synthesis of compound 1F of Example 1 utilizing 11E. MS (m/z) 361.66 [M+H]+.
出典と根拠
- ORDレコード
- ord-3f79cf2465e645d090f8d855c1d7b50c