Hydrochloric Acid → HCID 89580768、化合物
反応式
[OH:1][CH2:2][CH2:3][CH:4]([C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12]C)=[O:11])=[CH:8][CH:7]=1)[CH3:5].O.[OH-].[Li+].Cl>CO.O>[OH:1][CH2:2][CH2:3][CH:4]([C:6]1[CH:7]=[CH:8][C:9]([C:10]([OH:12])=[O:11])=[CH:14][CH:15]=1)[CH3:5]参加物
6
実験手順
To the solution of methyl 4-(4-hydroxybutan-2-yl)benzoate (354 mg, 1.7 mmol) in methanol (30 mL) and water (5 mL) was added lithium hydroxide hydrate (150 mg, 3.6 mmol) were added. The mixture was stirred at room temperature for 12 hours. Then the reaction mixture was acidified by hydrochloric acid aqueous solution (1N) to adjust pH=6 and extracted with dichloromethane (10 mL×3). The organic layers were combined and concentrated to give 4-(4-hydroxybutan-2-yl)benzoic acid (290 mg, 88%).
後処理
- additionwere added
- extractionextracted with dichloromethane (10 mL×3)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-3c00c550b0af46b58f43e321b86ea017
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09051269B2
反応ノート
読み込み中…