Triethyl phosphite → Benzyl (diethoxyphosphoryl)acetate

HRID 2170517ノート

反応式

HRID 2170517 の反応式
[CH2:1]([O:8][C:9](=[O:12])[CH2:10]Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:13]([O:15][P:16]([O:20]CC)[O:17][CH2:18][CH3:19])[CH3:14]>>[CH2:1]([O:8][C:9](=[O:12])[CH2:10][P:16]([O:17][CH2:18][CH3:19])([O:15][CH2:13][CH3:14])=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 31215Triethyl phosphiteHCID 62576Benzyl bromoacetate

生成物 1

HCID 281239Benzyl (diethoxyphosphoryl)acetate収率 80.3%

実験手順

The mixture of bromo-acetic acid benzyl ester (229 g, 1.0 mol) and phosphorous acid triethyl ester (166 g, 1.0 mol) was stirred at reflux for 10 hrs and the solvent was evaporated in vacuo to give crude (diethoxy-phosphoryl)-acetic acid benzyl ester (230 g) which was directly used for next step.

後処理

  1. temperatureat reflux for 10 hrs
  2. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-74ab55953b9748ec8c6d2eb897d01782
出典データセット
uspto-grants-2015_06
特許番号
US09051280B2

反応ノート

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