P-Cresol → Methyl (p-tolyloxy)acetate
反応式
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.C([O-])([O-])=O.[Cs+].[Cs+].Br[CH2:16][C:17]([O:19][CH3:20])=[O:18]>CN(C=O)C>[C:3]1([CH3:8])[CH:4]=[CH:5][C:6]([O:7][CH2:16][C:17]([O:19][CH3:20])=[O:18])=[CH:1][CH:2]=1参加物
5
実験手順
To a solution of p-cresol (2 mL, 19.1 mmol) in anhydrous DMF (50 mL) were added Cs2CO3 (8.1 g, 24.9 mmol) and methyl bromoacetate (1.9 mL, 20.1 mmol). The suspension was stirred at room temperature for 3 h. After dilution with ethyl acetate, the reaction mixture was washed with a 0.5 N HCl solution, a saturated solution of NaHCO3, and brine, dried on MgSO4, and concentrated. The resulting oil was purified by chromatography on silica gel (Hexane/ethyl acetate 8/2) to afford the title compound as a colorless oil (3.10 g, 90%).
後処理
- washAfter dilution with ethyl acetate, the reaction mixture was washed with a 0.5 N HCl solution
- dry with materiala saturated solution of NaHCO3, and brine, dried on MgSO4
- concentrationconcentrated
- customThe resulting oil was purified by chromatography on silica gel (Hexane/ethyl acetate 8/2)
出典と根拠
- ORDレコード
- ord-9ea61e8b2b854397a161c8d1f54b162f
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09051265B2
反応ノート
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