Tri(butyl)vinylstannane → 4-Formyl-3-vinylbenzonitrile

HRID 2170951ノート

反応式

HRID 2170951 の反応式
FC(F)(F)S(O[C:7]1[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][C:8]=1[CH:15]=[O:16])(=O)=O.[CH2:19](C([SnH3])=C(CCCC)CCCC)[CH2:20]CC>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH:15]([C:8]1[CH:9]=[CH:10][C:11]([C:13]#[N:14])=[CH:12][C:7]=1[CH:19]=[CH2:20])=[O:16]

参加物

4

反応物 2

HCID 21115800Tri(butyl)vinylstannaneHCID 593496385-Cyano-2-formylphenyl trifluoromethanesulfonate

生成物 1

HCID 540496494-Formyl-3-vinylbenzonitrile

試薬・触媒・溶媒 1

HCID 178418476HCID 178418476、化合物触媒

反応条件

温度
80 °C

実験手順

125 mg (0.18 mmol) of bis(triphenylphosphine)palladium(II) chloride are added to a solution of 1 g (3.58 mmol) of 5-cyano-2-formylphenyl trifluoromethanesulfonate and 1.15 ml (3.94 mmol) of tri-n-butylvinylstannane in 6 ml of anhydrous and degassed DMF under an argon atmosphere. The reaction mixture is then stirred at 80° C. for 90 min. Subsequently, 100 ml of 10% strength potassium fluoride solution are added, and the mixture is stirred at RT for 1 h. The suspension is extracted three times with 20 ml of ethyl acetate each time, and the combined organic phases are washed successively with saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic solution is dried over magnesium sulfate and concentrated. The residue (0.6 g) is employed without further purification in the next stage.

後処理

  1. customdegassed DMF under an argon atmosphere
  2. additionSubsequently, 100 ml of 10% strength potassium fluoride solution are added
  3. stirringthe mixture is stirred at RT for 1 h
  4. extractionThe suspension is extracted three times with 20 ml of ethyl acetate each time
  5. washthe combined organic phases are washed successively with saturated sodium bicarbonate solution and saturated sodium chloride solution
  6. dry with materialThe organic solution is dried over magnesium sulfate
  7. concentrationconcentrated
  8. customThe residue (0.6 g) is employed without further purification in the next stage

出典と根拠

ORDレコード
ord-fd1067736ccb4c048eaf1109a2586fd2
出典データセット
uspto-grants-2015_06
特許番号
US09051316B2

反応ノート

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