Chloromethyl Methyl Ether → HCID 67466846、化合物

HRID 2171161ノート

反応式

HRID 2171161 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([OH:10])[C:3]=1[OH:11].C(=O)([O-])[O-].[K+].[K+].[CH3:18][O:19][CH2:20]Cl>CC(C)=O>[Br:1][C:2]1[C:3]([O:11][CH2:18][O:19][CH3:20])=[C:4]([OH:10])[C:5]([O:8][CH3:9])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 7864Chloromethyl Methyl EtherHCID 11430Potassium CarbonateHCID 37058743-Bromo-6-methoxybenzene-1,2-diol

生成物 1

HCID 67466846HCID 67466846、化合物収率 38.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a stirring solution of 3-bromo-6-methoxybenzene-1,2-diol (500 mg, 2.28 mmol) in acetone (40 mL) at 0° C. was added potassium carbonate (314 mg, 2.28 mmol) and methoxymethyl chloride (184 mg, 2.28 mmol) and the resultant reaction mixture was stirred at RT for 2 h. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure Purification by column chromatography (silica gel, 0-8% ethyl acetate in pet ether) afforded 3-Bromo-6-methoxy-2-(methoxymethoxy)phenol as a liquid (230 mg, 38%).

後処理

  1. customthe resultant reaction mixture
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure Purification by column chromatography (silica gel, 0-8% ethyl acetate in pet ether)

出典と根拠

ORDレコード
ord-3ebb4dc5965346e8aa1d3e64a75aa62e
出典データセット
uspto-grants-2015_06
特許番号
US09051290B2

反応ノート

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