(3,5-Difluoro-4-((6-(trifluoromethyl)-3-pyridinyl)oxy)phenyl)methanol → (S)-7-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 2171377ノート

反応式

HRID 2171377 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:20][OH:21])[CH:5]=[C:6]([F:19])[C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:14]=1.Cl[C:23]1[CH:24]=[C:25]2[N:32](C(OC(C)(C)C)=O)[C@@H:31]([CH3:40])[CH2:30][N:26]2[C:27](=[O:29])[N:28]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([F:19])[C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]([C:15]([F:16])([F:17])[F:18])=[CH:13][CH:14]=1)[CH2:20][O:21][C:23]1[CH:24]=[C:25]2[NH:32][C@@H:31]([CH3:40])[CH2:30][N:26]2[C:27](=[O:29])[N:28]=1

参加物

3

反応物 2

HCID 66825487(3,5-Difluoro-4-((6-(trifluoromethyl)-3-pyridinyl)oxy)phenyl)methanolHCID 86728347(S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

生成物 1

HCID 86728353(S)-7-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

実験手順

The title compound was prepared by a procedure similar to that described for E9 starting from (3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)phenyl)methanol and (S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

出典と根拠

ORDレコード
ord-cd812909dd2847f7a4c81f98688fef79
出典データセット
uspto-grants-2015_06
特許番号
US09051325B2

反応ノート

読み込み中…