Ethyl Acetate → 6-Nitro-2-(2,3-dihydro-1,4-benzodioxine-6-yl)-quinazoline

反応式

[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([C:14]1[CH:19]=[CH:18][C:17]3[O:20][CH2:21][O:22][C:16]=3[CH:15]=1)[N:8]=[CH:7]2)([O-:3])=[O:2].[CH3:23]COC(C)=O>>[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([C:14]1[CH:19]=[CH:18][C:17]3[O:20][CH2:21][CH2:23][O:22][C:16]=3[CH:15]=1)[N:8]=[CH:7]2)([O-:3])=[O:2]

参加物

反応物 2

HCID 8857Ethyl Acetate

HCID 578631566-Nitro-2-(1,3-benzodioxole-5-yl)-quinazoline

生成物 1

HCID 578631426-Nitro-2-(2,3-dihydro-1,4-benzodioxine-6-yl)-quinazoline収率 70%

実験手順

This compound was synthesized in 70% yield, according to the procedure described in example 3 for 6-nitro-2-(3,4-methylendioxy-phenyl)-quinazoline. C16H11N3O4, MW: 309.28; mp: 263-265; TLC (tol/AcOEt 7/3) Rf=0.80.

後処理

customThis compound was synthesized in 70% yield

出典と根拠

ORDレコード: ord-68a2b86c0b4b463c8791861249cecab1
出典データセット: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08193353B2

反応ノート

読み込み中…