(4-((6-Chloropyridin-3-yl)oxy)-3-fluorophenyl)methanol → 7-((4-((6-chloropyridin-3-yl)oxy)-3-fluorobenzyl)oxy)-2,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 2171402ノート

反応式

HRID 2171402 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][C:10]=2[F:17])=[CH:4][CH:3]=1.Cl[C:19]1[CH:20]=[C:21]2[N:28](C(OC(C)(C)C)=O)[C:27]([CH3:37])([CH3:36])[CH2:26][N:22]2[C:23](=[O:25])[N:24]=1>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][O:16][C:19]3[CH:20]=[C:21]4[NH:28][C:27]([CH3:37])([CH3:36])[CH2:26][N:22]4[C:23](=[O:25])[N:24]=3)=[CH:11][C:10]=2[F:17])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 86676396(4-((6-Chloropyridin-3-yl)oxy)-3-fluorophenyl)methanolHCID 86728374tert-butyl 7-chloro-2,2-dimethyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

生成物 1

HCID 867283827-((4-((6-chloropyridin-3-yl)oxy)-3-fluorobenzyl)oxy)-2,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

実験手順

The title compound was prepared by a procedure similar to that described for E9 starting from (4-((6-chloropyridin-3-yl)oxy)-3-fluorophenyl)methanol and tert-butyl 7-chloro-2,2-dimethyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

出典と根拠

ORDレコード
ord-f0839fcc32834d9ba46f1a0071e84414
出典データセット
uspto-grants-2015_06
特許番号
US09051325B2

反応ノート

読み込み中…