(4-((2-Chloropyridin-4-yl)oxy)-3,5-difluorophenyl)methanol → 7-((4-((2-chloropyridin-4-yl)oxy)-3,5-difluorobenzyl)oxy)-2,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 2171403ノート

反応式

HRID 2171403 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[C:14]([F:15])=[CH:13][C:12]([CH2:16][OH:17])=[CH:11][C:10]=2[F:18])[CH:5]=[CH:4][N:3]=1.Cl[C:20]1[CH:21]=[C:22]2[N:29](C(OC(C)(C)C)=O)[C:28]([CH3:38])([CH3:37])[CH2:27][N:23]2[C:24](=[O:26])[N:25]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[C:14]([F:15])=[CH:13][C:12]([CH2:16][O:17][C:20]3[CH:21]=[C:22]4[NH:29][C:28]([CH3:38])([CH3:37])[CH2:27][N:23]4[C:24](=[O:26])[N:25]=3)=[CH:11][C:10]=2[F:18])[CH:5]=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 86728366(4-((2-Chloropyridin-4-yl)oxy)-3,5-difluorophenyl)methanolHCID 86728374tert-butyl 7-chloro-2,2-dimethyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

生成物 1

HCID 867283837-((4-((2-chloropyridin-4-yl)oxy)-3,5-difluorobenzyl)oxy)-2,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

実験手順

The title compound was prepared by a procedure similar to that described for E9 starting from (4-((2-chloropyridin-4-yl)oxy)-3,5-difluorophenyl)methanol and tert-butyl 7-chloro-2,2-dimethyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

出典と根拠

ORDレコード
ord-373289b5e94d42cfbd7b1a0c3dcdcaef
出典データセット
uspto-grants-2015_06
特許番号
US09051325B2

反応ノート

読み込み中…