3,4,5-Trifluorobenzyl alcohol → (R)-1,2-dimethyl-7-((3,4,5-trifluorobenzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 2171406ノート

反応式

HRID 2171406 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][OH:11])[CH:5]=[C:6]([F:9])[C:7]=1[F:8].Cl[C:13]1[CH:14]=[C:15]2[N:22]([CH3:23])[C@H:21]([CH3:24])[CH2:20][N:16]2[C:17](=[O:19])[N:18]=1>>[CH3:23][N:22]1[C:15]2[N:16]([C:17](=[O:19])[N:18]=[C:13]([O:11][CH2:10][C:4]3[CH:3]=[C:2]([F:1])[C:7]([F:8])=[C:6]([F:9])[CH:5]=3)[CH:14]=2)[CH2:20][C@H:21]1[CH3:24]

参加物

3

反応物 2

HCID 27770403,4,5-Trifluorobenzyl alcoholHCID 86728369(R)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

生成物 1

HCID 86728386(R)-1,2-dimethyl-7-((3,4,5-trifluorobenzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

実験手順

The title compound was prepared by a procedure similar to that described for E1 starting from (3,4,5-trifluorophenyl)methanol and (R)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

出典と根拠

ORDレコード
ord-1abc09ed62a440a39081e4d294b3f529
出典データセット
uspto-grants-2015_06
特許番号
US09051325B2

反応ノート

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