3,4,5-Trifluorobenzyl alcohol → (S)-2-methyl-7-((3,4,5-trifluorobenzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][OH:11])[CH:5]=[C:6]([F:9])[C:7]=1[F:8].Cl[C:13]1[CH:14]=[C:15]2[N:22](C(OC(C)(C)C)=O)[C@@H:21]([CH3:30])[CH2:20][N:16]2[C:17](=[O:19])[N:18]=1>>[CH3:30][C@H:21]1[CH2:20][N:16]2[C:17](=[O:19])[N:18]=[C:13]([O:11][CH2:10][C:4]3[CH:3]=[C:2]([F:1])[C:7]([F:8])=[C:6]([F:9])[CH:5]=3)[CH:14]=[C:15]2[NH:22]1参加物
3
実験手順
The title compound was prepared by a procedure similar to that described for E1 starting from (3,4,5-trifluorophenyl)methanol and (S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.
出典と根拠
- ORDレコード
- ord-4ff783b7b5ad4191a17fb3db87ec473d
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09051325B2
反応ノート
読み込み中…