Triphenylphosphine → Furo[3,2-c]pyridin-2-ylmethyltriphenylphosphonium bromide hydrochloride
反応式
[ClH:1].[Br:2][CH2:3][C:4]1[O:12][C:11]2[CH:10]=[CH:9][N:8]=[CH:7][C:6]=2[CH:5]=1.[CH:13]1[CH:18]=[CH:17][C:16]([P:19]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:15][CH:14]=1>C1COCC1.CCO>[ClH:1].[Br-:2].[O:12]1[C:11]2[CH:10]=[CH:9][N:8]=[CH:7][C:6]=2[CH:5]=[C:4]1[CH2:3][P+:19]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:16]1[CH:15]=[CH:14][CH:13]=[CH:18][CH:17]=1参加物
4
実験手順
A solution of 2-bromomethylfuro[3,2-c]pyridine hydrochloride (Preparation 5, 2.12 g, 8.5 mmol) and PPh3 (2.24 g, 8.5 mmol) in anhydrous THF-EtOH (1:1, 80 mL) was heated under reflux for 3 d. The solvents were removed under reduced pressure, then the residual solid was triturated with hot THF to furnish the title compound: RT=2.32 min.