Ethanol → Ethyl 2-fluoro-3-methylbenzoate
反応式
[F:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:17][CH2:18]O>>[F:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:17][CH3:18])=[O:5]参加物
4
反応条件
- 温度
- 90 °C
実験手順
2-Fluoro-3-methylbenzoic acid (8.0 g) was mixed with EtOH (100 ml), and concentrated sulfuric acid was added thereto, followed by stirring at 90° C. overnight. The reaction mixture was concentrated under reduced pressure, and EtOAc and water were then added thereto. The organic layer was washed with a saturated aqueous sodium hydrogen carbonate solution, then dried over Na2SO4, and concentrated under reduced pressure to obtain ethyl 2-fluoro-3-methylbenzoate (7.84 g).
後処理
- additionwas added
- concentrationThe reaction mixture was concentrated under reduced pressure, and EtOAc and water
- additionwere then added
- washThe organic layer was washed with a saturated aqueous sodium hydrogen carbonate solution
- dry with materialdried over Na2SO4
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-f6db904f0020462c833aaf92140e88fb
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09051283B2
反応ノート
読み込み中…