Boron tribromide → Benzofuran-5-ol
反応式
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][CH:9]=[CH:8][C:7]=2[CH:11]=1.B(Br)(Br)Br>ClCCl>[O:10]1[C:6]2[CH:5]=[CH:4][C:3]([OH:2])=[CH:11][C:7]=2[CH:8]=[CH:9]1参加物
4
実験手順
To a stirred solution of 5-methoxybenzofuran (1) (0.50 g, 3.38 mmol) in dichloromethane (15 mL), boron tribromide (16.87 mL, 16.87 mmol, 1M solution in dichloromethane) was added slowly at 0° C. The reaction mixture was warmed to room temperature and stirred for 4 hours. The reaction mixture was then cooled to 0° C., quenched with aqueous saturated NaHCO3 solution and extracted with dichloromethane (3×50 mL). The combined organic extracts were washed with brine (25 mL), dried over Na2SO4, and concentrated under reduced pressure to give compound (2) as an off white solid (300 mg) which was used in the next step without further purification.
後処理
- temperatureThe reaction mixture was then cooled to 0° C.
- customquenched with aqueous saturated NaHCO3 solution
- extractionextracted with dichloromethane (3×50 mL)
- washThe combined organic extracts were washed with brine (25 mL)
- dry with materialdried over Na2SO4
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-8d01c41013aa492d9175449692a5baf0
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08193363B2
反応ノート
読み込み中…