1-(Diphenylmethyl)azetidin-3-yl methanesulfonate → HCID 67154511、化合物

HRID 2172096ノート

反応式

HRID 2172096 の反応式
CS([O:5][CH:6]1[CH2:9][N:8]([CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:7]1)(=O)=O.[CH3:23]/[C:24](=[CH:27]\[CH3:28])/[CH2:25]O>>[CH:10]([N:8]1[CH2:9][CH:6]([O:5][CH2:23]/[C:24](/[CH3:25])=[CH:27]/[CH3:28])[CH2:7]1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

3

反応物 2

HCID 27587161-(Diphenylmethyl)azetidin-3-yl methanesulfonateHCID 64334172-Methyl-2-buten-1-OL

生成物 1

HCID 67154511HCID 67154511、化合物

実験手順

A solution of 1-benzhydrylazetidin-3-yl methanesulfonate (447 mg, 1.41 mmol) in (E)-2-methylbut-2-en-1-ol (1.2 g, 14.1 mmol) was stirred under microwaves at 110° C. for 30 minutes. After concentration to dryness, the residue was purified by chromatography on silica gel using petroleum ether/ethyl acetate (9:1) as eluent. The title product was obtained as a colorless oil (290 mg, 67%).

後処理

  1. concentrationAfter concentration to dryness
  2. customthe residue was purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-28cf6ce2bf3a42f29d89f2437b3a40f3
出典データセット
uspto-grants-2015_06
特許番号
US09051321B2

反応ノート

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