4-Isopropylacetophenone → 2-Bromo-1-(4-(propan-2-yl)phenyl)ethan-1-one
反応式
[CH3:1][CH:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([CH3:12])=[O:11])=[CH:6][CH:5]=1)[CH3:3].[Br:13]Br>C(OCC)(=O)C>[Br:13][CH2:12][C:10]([C:7]1[CH:6]=[CH:5][C:4]([CH:2]([CH3:1])[CH3:3])=[CH:9][CH:8]=1)=[O:11]参加物
4
実験手順
A solution of 4-isopropylacetophenone (65 g) in ethyl acetate (250 mL) is cooled to 0° C. and treated with bromine (65 g) dropwise. The mixture is stirred for 5 h, then quenched by the addition of water (250 mL). The phases are separated, and the aqueous layer is extracted with ethyl acetate. The organic phases are washed with satd. aq. NaHCO3 and brine, combined, dried over Na2SO4, filtered and evaporated to afford the product, 2-bromo-4′-isopropylacetophenone (64 g, 66%).
後処理
- customquenched by the addition of water (250 mL)
- customThe phases are separated
- extractionthe aqueous layer is extracted with ethyl acetate
- washThe organic phases are washed with satd
- dry with materialdried over Na2SO4
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-5c406c10b4f94b3ab03dc848c74a0922
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09051342B2
反応ノート
読み込み中…