Phosphorus oxychloride → 5-(4-isopropylphenyl)-1,3,4-oxadiazol-2(3H)-one
反応式
C(OC(=O)[CH2:5][NH:6][NH:7][C:8](=[O:18])[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:17])[CH3:16])=[CH:11][CH:10]=1)C.P(Cl)(Cl)(Cl)=[O:21]>>[CH:15]([C:12]1[CH:13]=[CH:14][C:9]([C:8]2[O:18][C:5](=[O:21])[NH:6][N:7]=2)=[CH:10][CH:11]=1)([CH3:17])[CH3:16]参加物
3
実験手順
Ethyl[2-(4-isopropylbenzoyl)hydrazino]acetate (4.85 g, 19.4 mmol) is treated with phosphorus oxychloride (50 mL), heated to reflux for 3 h, and then poured onto ice. The precipitate is collected and washed thoroughly with water and dried in the air to furnish 5-(4-isopropylphenyl)-1,3,4-oxadiazol-2(3H)-one (2.30 g, 58%) MS (ES+): m/e 205.
後処理
- temperatureheated
- temperatureto reflux for 3 h
- additionpoured onto ice
- customThe precipitate is collected
- washwashed thoroughly with water
- customdried in the air
出典と根拠
- ORDレコード
- ord-341e8dc483d74410aaed1e31c80f17a7
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09051342B2
反応ノート
読み込み中…