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Triethylamine → 2-Carbamyl-6-Hydroxybenzothiazole Dimethylphosphate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Phosphorochloridic acid, dimethyl ester | HCID 101863 | — |
| 反応物 | 2-Benzothiazolecarboxamide, 6-hydroxy- | HCID 9838911 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Carbamyl-6-Hydroxybenzothiazole Dimethylphosphate | HCID 86748732 | — |
反応手順
Three grams (0.015moles) of 2-carbamyl-6-hydroxybenzothiazole (ABT) was dissolved in 30 mLs of THF. Then 1.72 g (0.017 moles) triethylamine was added to the stirring reaction solution, followed immediately by the addition over 5 minutes of 2.6 g (0.018 moles) of dimethylchlorophosphate dissolved in 7 mLs of THF. This solution was stirred for 72 hours at room temperature.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05424440 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-34a06c3811de450caff1736c91de2d1f |
| 出典メモ | uspto-grants-1995_06 |