Triethylamine → 2-Carbamyl-6-Hydroxybenzothiazole Dimethylphosphate

HRID 21722

反応式

HRID 21722 の反応式
[C:1]([C:4]1[S:5][C:6]2[CH:12]=[C:11]([OH:13])[CH:10]=[CH:9][C:7]=2[N:8]=1)(=[O:3])[NH2:2].C(N(CC)CC)C.[CH3:21][O:22][P:23](Cl)([O:25]C)=[O:24]>C1COCC1>[CH3:21][O:22][P:23]([OH:25])([O:13][CH3:11])=[O:24].[C:1]([C:4]1[S:5][C:6]2[CH:12]=[C:11]([OH:13])[CH:10]=[CH:9][C:7]=2[N:8]=1)(=[O:3])[NH2:2]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 101863Phosphorochloridic acid, dimethyl esterHCID 98389112-Benzothiazolecarboxamide, 6-hydroxy-

生成物 1

HCID 867487322-Carbamyl-6-Hydroxybenzothiazole Dimethylphosphate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Three grams (0.015moles) of 2-carbamyl-6-hydroxybenzothiazole (ABT) was dissolved in 30 mLs of THF. Then 1.72 g (0.017 moles) triethylamine was added to the stirring reaction solution, followed immediately by the addition over 5 minutes of 2.6 g (0.018 moles) of dimethylchlorophosphate dissolved in 7 mLs of THF. This solution was stirred for 72 hours at room temperature.

出典と根拠

ORDレコード
ord-34a06c3811de450caff1736c91de2d1f
出典データセット
uspto-grants-1995_06
特許番号
US05424440

関連ノート

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