1-Bromo-3-chloropropane → HCID 86709383、化合物
反応式
Br[CH2:2][CH2:3][CH2:4][Cl:5].[F:6][C:7]([F:17])([F:16])[O:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1.C(=O)([O-])[O-].[K+].[K+]>CN1C(=O)CCC1>[Cl:5][CH2:4][CH2:3][CH2:2][O:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][C:7]([F:6])([F:16])[F:17])=[CH:10][CH:11]=1参加物
5
実験手順
1-Bromo-3-chloropropane (2.37 ml, 24 mmol), 4-(trifluoromethoxy)phenol (3.56 g, 20 mmol) and potassium carbonate (4.15 g, 30 mmol) were stirred in NMP (30 ml) overnight. After removing potassium carbonate by filtration, water was added to the mixture, followed by extraction with ethyl acetate. The organic layer was washed with water and dried over sodium sulfate. The solvent was distilled off, and the residue was fractionated and purified by silica gel column chromatography (hexane:ethyl acetate=89:11) to afford the title compound as a colorless oil (5.09 g, yield 99%).