Water → 4-(Trifluoromethyl)cyclohexane-1-carbaldehyde
反応式
[F:1][C:2]([F:12])([F:11])[C@@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][OH:10])[CH2:5][CH2:4]1.I(C1C=CC=CC=1C(O)=O)(=O)=O.O.C(OCC)(=O)C>CS(C)=O>[F:1][C:2]([F:11])([F:12])[CH:3]1[CH2:4][CH2:5][CH:6]([CH:9]=[O:10])[CH2:7][CH2:8]1参加物
6
実験手順
After dissolving [cis-4-(trifluoromethyl)cyclohexyl]methanol (2.04 g, 10.2 mmol) in dimethylsulfoxide (30 ml), 2-iodoxybenzoic acid (4.00 g, 14.3 mmol) was added thereto and stirred at room temperature overnight. Water and ethyl acetate were added to the reaction mixture, the insoluble matter was removed by filtration, and then the filtrate was separated into layers. The organic layer was washed with water and a saturated sodium chloride aqueous solution, dried over sodium sulfate, and concentrated to afford the title compound as a colorless oil (2.3 g, 100%).
後処理
- additionwas added
- customthe insoluble matter was removed by filtration
- customthe filtrate was separated into layers
- washThe organic layer was washed with water
- dry with materiala saturated sodium chloride aqueous solution, dried over sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-e8e52f2b652e41d387388aa0b2345957
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09051333B2
反応ノート
読み込み中…