Delta-Valerolactone → Pentanoic acid, 5-hydroxy-, methyl ester

温度

50 °C

To a solution of sodium methoxide (71.3 mg, 1.32 mmol) in anhydrous MeOH (4 ml), tetrahydro-pyran-2-one (1.32 g, 13.2 mmol) is added dropwise at room temperature under nitrogen. The mixture is stirred at 50° C. for 4 hours and filtered through a silica gel short column (eluent: diethyl ether). Collected filtrate is concentrated under reduced pressure to give 5-hydroxy-pentanoic acid methyl ester; 1H NMR (400 MHz, chloroform-d) ppm 1.57-1.76 (m, 4H), 2.35 (m, 2H), 3.65 (m, 5H).

1. filtrationfiltered through a silica gel short column (eluent: diethyl ether)
2. concentrationCollected filtrate is concentrated under reduced pressure

ORDレコード

ord-4f67e378ad1149a29304e130c34d5861

出典データセット

uspto-grants-2012_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08193349B2