3,4,5,6-Tetrahydrophthalic anhydride → N-(2,4-Dichloro-6-fluorobenzothiazol-7-yl)-3,4,5,6-tetrahydrophthalimide

HRID 21723

反応式

HRID 21723 の反応式
[NH2:1][C:2]1[C:10]2[S:9][C:8]([Cl:11])=[N:7][C:6]=2[C:5]([Cl:12])=[CH:4][C:3]=1[F:13].[C:14]1(=O)[O:19][C:17](=[O:18])[C:16]2[CH2:20][CH2:21][CH2:22][CH2:23][C:15]1=2>C(O)(=O)C>[Cl:11][C:8]1[S:9][C:10]2[C:2]([N:1]3[C:17](=[O:18])[C:16]4[CH2:20][CH2:21][CH2:22][CH2:23][C:15]=4[C:14]3=[O:19])=[C:3]([F:13])[CH:4]=[C:5]([Cl:12])[C:6]=2[N:7]=1

参加物

4

反応物 2

HCID 124753,4,5,6-Tetrahydrophthalic anhydrideHCID 199334577-Amino-2,4-dichloro-6-fluorobenzothiazole

生成物 1

HCID 19933466N-(2,4-Dichloro-6-fluorobenzothiazol-7-yl)-3,4,5,6-tetrahydrophthalimide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 6 g 7-amino-2,4-dichloro-6-fluoro-benzothiazole and 4.3 g 3,4,5,6-tetrahydrophthalic anhydride in 50 ml acetic acid was heated under reflux for 5 hours. After cooling, the reaction solution was poured into 200 ml ice-water and the resulting crystals were separated off. They were dried at 50° C. in vacuo and then purified by column chromatography. Yield: 6.6 g=70% of theory m.p.: 139°-141° C.

後処理

  1. temperatureunder reflux for 5 hours
  2. temperatureAfter cooling
  3. customthe resulting crystals were separated off
  4. customThey were dried at 50° C. in vacuo
  5. custompurified by column chromatography

出典と根拠

ORDレコード
ord-a7ad4b452cd840e4b80e1f788cd0e5ae
出典データセット
uspto-grants-1995_06
特許番号
US05424443

関連ノート

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